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. Author manuscript; available in PMC: 2010 Aug 1.
Published in final edited form as: Cancer Res. 2009 Jul 21;69(15):6223–6231. doi: 10.1158/0008-5472.CAN-09-0187

Figure 6. MMP-1/PAR1 Blockade Inhibits Breast Tumor Metastasis to the Lung.

Figure 6

(A) MDA-MB-231/GFP cells (2 × 106 cells) were introduced via the tail vein of female nude mice (n = 5-10 mice per group). Vehicle (10% DMSO), P1pal-7 (10 mg/kg), or FN439 (5 mg/kg) were administered 6 d/wk for 6 wks. Lungs were photographed (Left Column) and sectioned for H&E staining (Right Column; 4× magnification). T = Tumor Nodule. (B) Number of metastatic tumor nodules per lung as counted under a light microscope. ***p < 0.001.