Table 3.
Association analysis of APOA1/C3/A4/A5 SNPs with TG response to fenofibratea
| Phenotypic mean ± SE |
||||||
|---|---|---|---|---|---|---|
| SNP | Alleles | MAF | 1/1 (n) | 1/2 (n) | 2/2 (n) | P |
| APOA5_S19W | C/G | 0.068 | − 2.052 ± 0.109 (− 44.9 ± 57.4) (763) | − 3.236 ± 0.559 (− 77.5 ± 107.2) (95) | − 8.562 ± 0.583 (− 212.3 ± 78.5) (3) | 0.0004b |
| APOA5_M1123 | G/A | 0.062 | − 2.134 ± 0.123 (762) | − 2.883 ± 0.376 (97) | − 3.021 ± 0.357 (2) | 0.054 |
| APOA4_A5INTER | C/T | 0.353 | − 2.372 ± 0.285 (370) | − 2.313 ± 0.176 (395) | − 2.040 ± 0.165 (96) | 0.394 |
| APOA4_T347S | A/T | 0.183 | − 2.305 ± 0.159 (588) | − 1.947 ± 0.140 (245) | − 2.172 ± 0.373 (28) | 0.186 |
| APOA4_N147S | G/A | 0.130 | − 1.945 ± 0.109 (− 43.3 ± 54.5) (656) | − 2.813 ± 0.735 (− 50.1 ± 61.2) (189) | − 3.070 ± 0.335 (− 68.7 ± 93.5) (16) | 0.004 |
| APOA4_T29T | G/A | 0.173 | − 2.009 ± 0.123 (591) | − 2.608 ± 0.277 (249) | − 3.060 ± 0.768 (21) | 0.067 |
| APOA4_M35 | C/G | 0.051 | − 2.216 ± 0.132 (781) | − 2.106 ± 0.210 (80) | 0.654 | |
| APOC3_M2886 | C/A | 0.348 | − 2.313 ± 0.290 (382) | − 2.342 ± 0.187 (382) | − 2.032 ± 0.159 (97) | 0.338 |
| APOC3_M640 | A/C | 0.360 | − 2.051 ± 0.158 (368) | − 2.337 ± 0.174 (392) | − 2.218 ± 0.291 (98) | 0.387 |
| APOC3_M482 | A/G | 0.250 | − 2.712 ± 0.368 (− 57.7 ± 50.4) (505) | − 2.549 ± 0.221 (− 57.1 ± 79.4) (306) | − 1.950 ± 0.131 (− 43.3 ± 57.0) (46) | 0.026 |
| APOC3_M455 | G/A | 0.356 | − 2.275 ± 0.298 (376) | − 2.276 ± 0.174 (391) | − 2.106 ± 0.169 (94) | 0.736 |
| APOC3_G34G | T/C | 0.262 | − 1.903 ± 0.108 (− 40.8 ± 46.3) (480) | − 2.462 ± 0.207 (− 56.7 ± 76.2) (318) | − 3.282 ± 0.703 (− 71.7 ± 112.1) (63) | 0.006 |
| APOC3_3U386 | C/G | 0.094 | − 2.013 ± 0.110 (− 44.6 ± 54.7) (718) | − 3.218 ± 0.437 (− 64.8 ± 82.7) (138) | − 3.994 ± 1.627 (− 71.0 ± 103.6) (5) | 0.018 |
| APOA1_M75 | A/G | 0.160 | − 2.161 ± 0.120 (603) | − 2.198 ± 0.257 (226) | − 3.136 ± 0.660 (32) | 0.354 |
| APOA1_M2630 | A/G | 0.292 | − 3.088 ± 0.710 (433) | − 2.254 ± 0.191 (359) | − 2.029 ± 0.120 (69) | 0.194 |
| APOA1_M2803 | G/A | 0.353 | − 1.999 ± 0.136 (374) | − 2.249 ± 0.172 (389) | − 2.827 ± 0.531 (98) | 0.173 |
| APOA1_M3012 | A/G | 0.128 | − 3.642 ± 0.898 (657) | − 2.078 ± 0.270 (181) | − 2.197 ± 0.123 (21) | 0.259 |
Bold italic indicates minor alleles. P values less than 0.05 are shown in boldface.
MAF, minor allele frequeny; SNP, single nucleotide polymorphism; TG, triglyceride.
a
Response to fenofibrate (phenotype) was represented by slope estimated from growth curve models. Numbers in brackets are absolute changes of TG (mg/dl) in response to fenofibrate.
b
Significant associations after Bonferroni’s correction. The significance threshold is P < 0.003 (0.05/17).