Table 4.
Association analysis of of APOA1/C3/A4/A5 SNPs with HDL response to fenofibratea
| Phenotypic mean ± SE |
||||||
|---|---|---|---|---|---|---|
| SNP | Alleles | MAF | 1/1 (n) | 1/2 (n) | 2/2 (n) | P |
| APOA5_S19W | C/G | 0.068 | 0.120 ± 0.001 (2.72 ± 5.70) (763) | 0.117 ± 0.002 (4.49 ± 5.48) (95) | 0.096 ± 0.006 (6.66 ± 4.72) (3) | 0.002b |
| APOA5_M1123 | G/A | 0.062 | 0.120 ± 0.001 (762) | 0.116 ± 0.003 (97) | 0.117 ± 0.002 (2) | 0.270 |
| APOA4_A5INTER | C/T | 0.353 | 0.120 ± 0.003 (370) | 0.121 ± 0.001 (395) | 0.119 ± 0.001 (96) | 0.510 |
| APOA4_T347S | A/T | 0.183 | 0.120 ± 0.001 (588) | 0.120 ± 0.001 (245) | 0.118 ± 0.006 (28) | 0.947 |
| APOA4_N147S | G/A | 0.130 | 0.119 ± 0.001 (656) | 0.122 ± 0.002 (189) | 0.122 ± 0.007 (16) | 0.487 |
| APOA4_T29T | G/A | 0.173 | 0.119 ± 0.001 (591) | 0.121 ± 0.001 (249) | 0.122 ± 0.006 (21) | 0.553 |
| APOA4_M35 | C/G | 0.051 | 0.120 ± 0.001 (781) | 0.117 ± 0.003 (80) | 0.325 | |
| APOC3_M2886 | C/A | 0.348 | 0.121 ± 0.002 (382) | 0.121 ± 0.001 (382) | 0.119 ± 0.001 (97) | 0.502 |
| APOC3_M640 | A/C | 0.360 | 0.118 ± 0.001 (368) | 0.121 ± 0.001 (392) | 0.121 ± 0.002 (98) | 0.273 |
| APOC3_M482 | A/G | 0.250 | 0.124 ± 0.004 (505) | 0.120 ± 0.001 (306) | 0.119 ± 0.001 (46) | 0.441 |
| APOC3_M455 | G/A | 0.356 | 0.120 ± 0.002 (376) | 0.121 ± 0.001 (391) | 0.119 ± 0.001 (94) | 0.468 |
| APOC3_G34G | T/C | 0.262 | 0.119 ± 0.001 (480) | 0.121 ± 0.001 (318) | 0.120 ± 0.004 (63) | 0.772 |
| APOC3_3U386 | C/G | 0.094 | 0.120 ± 0.001 (718) | 0.118 ± 0.002 (138) | 0.135 ± 0.012 (5) | 0.354 |
| APOA1_M75 | A/G | 0.160 | 0.118 ± 0.001 (603) | 0.122 ± 0.001 (226) | 0.125 ± 0.006 (32) | 0.216 |
| APOA1_M2630 | A/G | 0.292 | 0.122 ± 0.003 (433) | 0.122 ± 0.001 (359) | 0.118 ± 0.001 (69) | 0.112 |
| APOA1_M2803 | G/A | 0.353 | 0.118 ± 0.001 (374) | 0.122 ± 0.001 (389) | 0.120 ± 0.002 (98) | 0.132 |
| APOA1_M3012 | A/G | 0.128 | 0.120 ± 0.008 (657) | 0.122 ± 0.002 (181) | 0.119 ± 0.001 (21) | 0.355 |
Numbers in brackets are absolute changes of HDL (mg/dl) in response to fenofibrate. Bold italic indicates minor alleles. P values less than 0.05 are shown in boldface.
MAF, minor allele frequency; SNP, single nucleotide polymorphism; HDL, high-density lipoprotein.
a
Response to fenofibrate (phenotype) was represented by slope estimated from growth curve models.
b
Indicates significant associations after Bonferroni’s correction. The significance threshold is P < 0.003 (0.05/17).