Table 5.

Association of APOA1/C3/A4/A5 common haplotypes with lipid response to fenofibrate^a

		Haplotype–genotype mean (SE) for TG response					Haplotype–genotype mean (SE) for HDL cholesterol response
Haplotypeb	Haplotype frequency	+ / + c	± d	− / − e	Haplotype P	Global P	+ / + c	± d	− / − e	Haplotype P	Global P
Hap1 CAAACGGCCA	0.462	− 1.995 (0.211)	− 2.293 (0.149)	− 2.113 (0.207)	0.429	0.003*	0.112 (0.008)	0.128 (0.007)	0.132 (0.007)	0.202	0.014
Hap2 CAAACTGCCA	0.071	− 0.743 (0.167)	− 1.851 (0.186)	− 2.230 (0.134)	< 0.0001*		0.113 (0.005)	0.111 (0.010)	0.128 (0.004)	0.031
Hap3 CAAACGGTCG	0.067	− 0.256 (0.999)	− 1.773 (0.333)	− 2.238 (0.137)	0.035		0.123 (0.046)	0.126 (0.015)	0.126 (0.004)	0.997
Hap4 CAAAGTACCG	0.048	− 1.172 (0.476)	− 2.476 (0.315)	− 2.150 (0.131)	0.077		0.052 (0.022)	0.121 (0.017)	0.126 (0.004)	0.011
Hap5 CGGGCTATGG	0.044	− 1.052 (0.162)	− 2.136 (0.121)	− 2.732 (0.508)	< 0.0001*		0.077 (0.006)	0.143 (0.015)	0.125 (0.004)	< .0001*
Hap6 GAAACGGTCG	0.044	− 4.940 (1.818)	− 3.951 (1.731)	− 2.088 (0.108)	0.231		0.159 (0.032)	0.195 (0.026)	0.123 (0.004)	0.032

HDL, high-density lipoprotein; TG, triglyceride.

^aResponse to fenofibrate (phenotype) was represented by slope estimate from growth curve models.

^bHaplotypes were determined using the Haploview software for tag SNPs following the order of APOA5_S19W, APOA5_M1123, APOA4_N147S, APOA4_T29T, APOA4_M35, APOC3_M640, APOC3_M482, APOC3_G34G, APOC3_3U386, and APOA1_M2803. To maximize the statistical power, we only tested associations for the haplotypes with estimated frequencies greater than 0.04.

^cTwo copies of the haplotype of interest.

^dOne copy of the haplotype of interest.

^eAny other haplotype combination.

^*P < 0.05 are shown in boldface; indicates significant associations after Bonferroni’s correction. The significance threshold is P < 0.008 (0.05/6).