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. Author manuscript; available in PMC: 2009 Aug 27.
Published in final edited form as: Toxicol Pathol. 2009 Jun 17;37(5):629–643. doi: 10.1177/0192623309339605

Figure 2.

Figure 2

Representative photomicrographs demonstrating expression of inducible nitric oxide synthase (iNOS) and nitrotyrosine in control, gentamicin (Gen)-, or cisplatin (Cis)-treated rats. (A) Expression of iNOS was not found in the epithelial cells of proximal tubules in eighty-day-old, saline-treated control rats in the Gen study; ×200. (B) Expression of iNOS was observed in the epithelial cells of proximal tubules in eighty-day-old rats treated with 100 mg/kg/day of Gen for fourteen days; ×200. (C) Nitrotyrosine expression was not found in the epithelial cells of proximal tubules in eighty-day-old, saline-treated control rats in the Gen study; ×200. (D) Nitrotyrosine expression was found predominantly in the epithelial cells of proximal tubules in eighty-day-old rats treated with 100 mg/kg/day of Gen for fourteen days; ×200. (E) No iNOS expression was found in the medulla of forty-day-old, saline-treated control rats in the Cis study; ×400. (F) Expression of iNOS was found predominantly in the tubular epithelial cells of the loop of Henle, but slight expression of iNOS was also discernible in some of the collecting duct epithelial cells in forty-day-old rats treated with 3 mg/kg Cis; ×400. (G) No nitrotyrosine expression was found in the medulla in forty-day-old, saline-treated control rats in the Cis study; ×400. (H) Nitrotyrosine expression was found in the tubular epithelial cells of the loop of Henle, but not in the collecting duct tubular cells in forty-day-old rats treated with 3 mg/kg Cis. ×400.