Table 1.

Measured responses to cellular perturbations.

Perturbation	Number of differentially expressed genes1	Number of genetic hits2	Overlap
Growth arrest (HU) 20,79	59	86	0
DNA damage (MMS) 4,13	198	1448	43
ER stress (tunicamycin) 3,20	200	127	5
Fatty acid metabolism (oleate) 9,80	269	103	9
ATP synthesis block (arsenic)2	828	50	9
Protein biosynthesis (cycloheximide) 20,79	20	164	0
Gene inactivation, screen complete (24 data sets 19,20,81,82)3	27	130	0
Gene inactivation, screen incomplete (149 data sets 19,20)3	24	12	0

¹Differentially expressed genes were defined as those showing at least a 2-fold change in expression following the perturbation or as defined in the original papers.

²Number of genes whose genetic manipulation affects the phenotype of perturbed cells relative to wild type.

³Median results are shown.