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. Author manuscript; available in PMC: 2010 Jun 12.
Published in final edited form as: Mol Cell. 2009 Jun 12;34(5):521–533. doi: 10.1016/j.molcel.2009.05.016

Figure 1.

Figure 1

RVB1 and RVB2 are involved in multiple cellular pathways. Schematic showing involvement of RVBs in transcription, DNA damage response, small nucleolar ribonucleotide protein (snoRNPs) assembly, cellular transformation, cancer metastasis, apoptosis, mitosis and development. RVBs act in (i) transcription by regulating function of Ino80, Swr1 and TIP60 complexes, (ii) DNA damage response through TIP60 and Ino80, (iii) snoRNP assembly by affecting maturation of snoRNAs and localization of Nop1 and Gar1, (iv) cellular transformation by c-Myc and β-catenin function, (v) cancer metastasis by regulating expression of KAI1 through TIP60 and β-catenin, (vi) apoptosis through TIP60, (vii) mitosis by regulating assembly of microtubules and (viii) development through c-Myc pathway.