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RVBs are required for small nucleoprotein (snoRNP) assembly. (A) and (B) Schematics of box C/D and H/ACA small nucleolar ribonuleotide (snoRNA) family. (C) RVB bind to the stem of snoRNA and are required maturation of snoRNAs. Loss of RVB affects proper localization of two core snoRNP proteins, Nop1 and Gar1 that associate with snoRNAs of box C/D family and H/ACA family, respectively.
