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. Author manuscript; available in PMC: 2010 Jun 12.
Published in final edited form as: Mol Cell. 2009 Jun 12;34(5):521–533. doi: 10.1016/j.molcel.2009.05.016

Figure 6.

Figure 6

RVBs are involved in cellular transformation and cancer metastasis. (A) Cellular transformation by c-Myc and β-catenin requires functional RVBs. Expression of Walker B mutant of RVB1 acts as a dominant negative form of RVB1 and inhibits cellular transformation. (B) RVB1-TIP60 and RVB2-β-catenin complexes function antagonistically. RVB1-TIP60 complex act as an activator of KAI1 expression whereas RVB2-β-catenin complex act as a repressor. Inhibition of expression of KAI1 transforms cells from non-metaststic to metastatic state.