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. 2009 Sep 4;4(9):e6808. doi: 10.1371/journal.pone.0006808

Figure 1. Leptin Increases Muscle Mass and Muscle Fiber Size of ob/ob Mice.

Figure 1

(A) Gastrocnemius (GAS), extensor digitorum longus (EDL) and soleus (SOL) muscle weights of PBS (open), pair-fed (gray) and leptin-treated (closed) wild type and ob/ob mice (n = 9–10 per group). *P<0.05, **P<0.01 and ***P<0.001. (B) Cross-sectional area (CSA) of GAS, EDL and SOL muscle fibers of PBS (open), pair-fed (gray) and leptin-treated (closed) wild type and ob/ob mice (approximately 100 fibers/muscle from 3 mice/group). **P<0.001 and ***P<0.0001. (C) Representative histological sections of hematoxylin-eosin-stained GAS, EDL and SOL muscles of wild type and ob/ob mice. Scale bars = 200 µm. Results are presented as mean±SEM. G: genotype, T: treatment.