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. 2007 Dec 28;18(9):2117–2131. doi: 10.1093/cercor/bhm238

Figure 4.

Figure 4.

Increasing COUP-TFI expression promotes neurogenesis. (A–F′) D6/COUP-TFI cortex shows increasing PP/CP thickness from E11.5 through E13.5 based on expression of β-III-tubulin (A–C′, red) and Tbr1 (D–F′). At E13.5 (F–F′), the D6/COUP-TFI VZ (F′, asterisk) ectopically expresses Tbr1, a postmitotic marker. Each staining has been performed at least 3 times. (G-H) Quantification of PP and CP width during development (E11.5 to P0 for D6 and E13.5 to E18.5 for COUP-TFI–/–). In order to quantify CP thickness in the D6 line, we measured dorsal pallium (box in A′, B′, and C′). To quantify CP thickness in the COUP-TFI–/– line, we measure ventral pallium/lateral pallium (box in Fig. S2B′′). (G) The plot shows the initial (E11.5–E13.5) CP overgrowth in D6 animals, followed by the decrease after E13.5. (H) The plot shows the overall reduced ventral CP thickness in COUP-TFI–/–.