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. 2007 Dec 28;18(9):2117–2131. doi: 10.1093/cercor/bhm238

Figure 9.

Figure 9.

Model for COUP-TFI function in regulating proliferation, differentiation, and patterning. (A) COUP-TFI dosage regulates RTK signaling pathways through downregulation of Mapk/Erk and PI3K/Akt activity. These changes promote progenitor cells to leave the cell cycle (reducing the numbers of both VZ and SVZ cells) and to differentiate into Tbr2+ and Tbr1+ neurons. D6/COUP-TFI promotes expression of Fgfr3; we hypothesize that this Fgf receptor may participate in the proliferation-to-differentiation switch. (B) COUP-TFI promotes ventral fate in the cortical primordium. Disruption of the COUP-TFI gradient changes D/V molecular properties in the CP, as revealed by the expression of ventral (ER81 and p75, green) and dorsal (β-catenin and Fezl, violet) markers.