Figure 4.

Mapping developmental effects on cortical thickness. Correlations between medial cortical thickness and age are mapped locally and visualized, separately for patients with 22q11.2DS and typically developing controls. (a and b) Correlational (r) maps, indicating the strength of the association between cortical thickness and age across the medial surface of the brain. (c and d) P maps representing the significance of these correlations. Red colors indicate brain regions in which significant cortical thinning with increasing age was detected. Consistent with independent studies of cortical development over this age span (Vidal et al. 2006), controls showed localized regions of cortical thinning primarily in superior parietal and cingulate cortex associated with increasing age, but children with 22q11.2DS showed a more posterior and more widespread pattern of age-related cortical thinning, particularly in ventromedial occipital–temporal regions.