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Six individuals with Emanuel syndrome, demonstrating evolution of facial features with age. Approximate ages are: a) 12 months and 13 years; b) 8 months and 15 years; c) 24 months and 8 years; d and e) 4 years and 28 years; f) 30 months and 20 years. Patients d and e are siblings. Note that, as expected, there is facial elongation and growth of the mandible with age. Features remain fine, without significant coarsening.
