Table 8.

Correlations (Pearson’s r) between the loss rate in hippocampal volume and various biological and environmental covariates broken down by diagnosis

	AD		N	MCI		N	Normal		N
	Left	Right		Left	Right		Left	Right
GD baseline	0.071	0.030	97	−0.069	0.030	245	−0.135	−0.055	148
GD change	−0.190a	−0.122	97	−0.127a	−0.068	245	−0.018	0.017	148
Homocys	0.073	−0.018	97	−0.114a	−0.066	245	−0.011	0.105	148
Systole	−0.003	−0.219a	97	0.052	−0.007	245	−0.051	0.030	148
Diastole	0.010	−0.093	97	0.060	0.022	245	0.091	−0.017	148
Education	−0.131	0.036	97	−0.021	−0.038	245	0.039	−0.138a	148

None of these associations proved significant when all 3 diagnostic groups were combined (Table 7), but some were significant in groups split by diagnosis. Given that 18 statistical tests were performed, a Bonferroni correction should be applied (0.05/18), so these linkages should be regarded as exploratory due to the large number of covariates tested, and require independent confirmation. No association exceeded p=0.01.

^ap<0.05.