Table 1.

Main effect of nicotine

	Brain region	Side	Center of mass (mm)			Brodmann areas	Number of 1-μL voxels
			x	y	z
Nicotine reduced activation
1	MFG and IFG	L	−46.1	37	15.9	46	1002
2	MFG	L	−43.9	8.9	34.8	9	662
3	Pre- and postcentral gyrus	R	32.7	−26.8	52.2	3, 4	511
4	MTG and ITG	L	−53.8	−41.5	−10	20, 21, 37	676
5	Fusiform gyrus	L	−30	−36	−13.8	37	510
6	Primary visual cortex	R	13.6	−89	6	17	1855
7	Middle occipital gyrus, cuneus	L	−21.7	−97.5	5.1	18	1144
8	Middle and inferior occipital gyrus	R	30.3	−78.3	−3.1	18, 19	605
9	Middle and inferior occipital gyrus	L	−31.9	−86.9	−6.6	18	588
10	Thalamus	L	−12.2	−13.1	13.8	—	712
11	Thalamus	R	8.3	−8.4	7.1	—	461
Nicotine reduced deactivation
12	Rostral anterior cingulate and medial frontal gyrus	L	−10	44.9	1	10, 32	827
13	MTG	L	−37.9	16.2	50.2	6, 8	916
14	Parahippocampal gyrus	L	−22.9	−12.9	−22.4	35	828
15	White matter, superior to insula	R	34.8	−18.2	25.5	—	480

Note: The numbering corresponds to ROIs in Figure 3. L, left; R, right.