Table 2.
Models for prediction of progression to permanent atrial fibrillation: role of body mass index and left atrial size
| Entire population (n = 3,248) | HR (95% CI) | P-Value |
|---|---|---|
| BMI as continuous variable (per kg/m2 increase) | ||
| Adjusted for age and sex | 1.04 (1.03-1.06) | <0.0001 |
| Adjusted for clinical variables | 1.04 (1.02-1.05) | <0.0001 |
| Adjusted for clinical variablesa and interim MI/CHF | 1.03 (1.01-1.04) | 0.0003 |
| BMI as a categorical variable (per level increase) | ||
| Adjusted for age and sex | ||
| Normal BMI | 1.000 | |
| Overweight | 1.13 (0.92–1.39) | 0.2415 |
| Obese | 1.54 (1.21–1.95) | 0.0004 |
| Severely obese | 1.87 (1.40–2.51) | <0.0001 |
| Adjusted for age, sex, and other clinical variablesa | ||
| Normal | 1.000 | |
| Overweight | 1.11 (0.90–1.37) | 0.3482 |
| Obese | 1.39 (1.09–1.79) | 0.0084 |
| Severely obese | 1.66 (1.21–2.24) | 0.0015 |
| Adjusted for clinical variablesa and interim MI/CHF | ||
| Normal | 1.000 | |
| Overweight | 1.09 (0.88–1.35) | 0.4147 |
| Obese | 1.30 (1.01–1.66) | 0.0408 |
| Severely Obese | 1.48 (1.08–2.01) | 0.0134 |
| Subgroup with echo parameters (n = 744) | HR (95% CI) | P-Value |
| BMI as continuous variable (per kg/m2 increase) | ||
| Adjusted for age, sex and LA volume | 1.05 (1.02–1.07) | <0.0001 |
| Adjusted for age, sex, other clinical variablesa, and LA volume | 1.05 (1.02–1.08) | 0.0015 |
| Adjusted for age, sex, other clinical variablesa, and interim MI/CHF | 1.03 (1.01–1.06) | 0.0206 |
| BMI as a categorical variable (per level increase) | ||
| Age, sex, and LA volume adjusted | ||
| Normal | 1.000 | |
| Overweight | 0.77 (0.50–1.19) | 0.2416 |
| Obese | 1.42 (0.89–2.26) | 0.1370 |
| Severely obese | 1.89 (1.11–3.21) | 0.0193 |
| Adjusted for age, sex, other clinical variablesa, and LA volume | ||
| Normal | 1.000 | |
| Overweight | 0.71 (0.45–1.12) | 0.1413 |
| Obese | 1.15 (0.70–1.88) | 0.5915 |
| Severely obese | 1.59 (0.89–2.83) | 0.1152 |
| Adjusted for age, sex, other clinical variablesa, interim MI/CHF and LA volume | ||
| Normal | 1.000 | |
| Overweight | 0.68 (0.42–1.08) | 0.0985 |
| Obese | 1.04 (0.64–1.71) | 0.8679 |
| Severely obese | 1.39 (0.78–2.49) | 0.2659 |
aClinical variables adjusted for include history of hypertension, valvular heart disease, myocardial infarction, congestive heart failure, smoking, chronic pulmonary disease, systolic and diastolic blood pressures at baseline AF diagnosis (see section Methods for details). History of CHF, valvular heart disease, hypertension, and diastolic blood pressure remained significant as predictors in all the above multivariable models adjusting for clinical covariates.