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. 2009 Aug 24;186(4):571–587. doi: 10.1083/jcb.200812176

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© 2009 Oser et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 3. — Barbed ends at invadopodium precursors peak beginning 1 min after EGF stimulation. (A) Image showing that barbed ends localize with Tks5 at areas of matrix degradation (arrowheads). Bar, 10 μm. (B and C) The barbed end assay in response to EGF using MTLn3 cells. (B) Representative images of barbed ends and F-actin at invadopodium precursors in response to EGF. Insets here and throughout the figures show close ups of invadopodium precursors. Bar, 10 μm. (C) Quantification of barbed end intensity at invadopodium precursors normalized to 0 s (sec) EGF. n = number of invadopodium precursors; three independent experiments: 0 s (39), 60 (73), 120 (109), 180 (28). P values are compared with 0 s. (D) Quantification of barbed end intensity at invadopodium precursors in response to EGF measured using a GFP-actin live cell method (Lorenz et al., 2004a). n = 21 invadopodium precursors.