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. 2009 Aug 24;186(4):525–540. doi: 10.1083/jcb.200905070

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© 2009 Rolland et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jcb.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 3. — EM analysis of CED-9–induced mitochondrial fusion and FZO-1–induced mitochondrial aggregation. (A) Transgenic lines expressing mitogfp alone (P_myo-3 mitogfp) show wild-type muscle mitochondria lying just below the sarcomere. Note its abundant internal cristae. (B–D) Transgenic lines expressing mitogfp in the presence of ced-9(wt) (P_myo-3 mitogfp + P_myo-3 ced-9(wt) (3′UTRsmg)) show mitochondria with abundant cristae. Three typical structures were observed. (B) Mitochondria form elongated and branched structures. These giant mitochondria seem fused. Nearby tubes may be part of these giant mitochondria; however, in one thin section, it is not possible to know for sure. (C) Mitochondria have smaller diameter and are closely clustered. In some cases, neighboring mitochondria may be physically attached to one another through the OMM. (D) Mitochondria lie closely together, and some show nested profiles in which one tube is completely enveloped by another. Cristae in some cases run circumferentially inside narrow outer tubes. (E) Transgenic lines expressing mitogfp in the presence of fzo-1 (P_myo-3 mitogfp + P_myo-3 fzo-1 (3′UTRsmg)) show mitochondria with abundant cristae, which are closely clustered and tend to have smaller diameters. In many cases, neighboring mitochondria may be physically attached to one another through the OMM. Insets show a magnified view of the indicated area. Bars, 500 nm.