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Homology models of the 5-HT3 receptors where Pro308, in the trans (left) and cis (right) configurations, and selected surrounding residues are shown explicitly. Pro308 and the adjacent residues Thr207 and Leu209 are in the M2−M3 loop, Glu213 is in the F loop, Arg245 is at the boundary between the extracellular and the transmembrane domains, and Tyr250 is at the start of the M1 helix.
