. Author manuscript; available in PMC: 2009 Aug 27.

Published in final edited form as: Org Lett. 2006 Apr 13;8(8):1729–1732. doi: 10.1021/ol0603211

Table 1.

IC₅₀ values.^a

compound	structure	IC₅₀ µM
10		61 ± 4
11		40 ± 5
12		54 ± 8
13		79 ± 8
14		>100
15		87 ± 6
16		72 ± 5
17		75 ± 4
18		0.41 ± 0.03
19		3.1 ± 0.9
20		73 ± 5
21		>100

Assays were conducted at various inhibitor concentrations at 22.5 °C, pH 7.4 in 40 mM HEPES 0.01% (W/V) Tween® 20, 5 µM SNAPtide substrate and 200 nM enzyme.