. Author manuscript; available in PMC: 2010 May 1.

Published in final edited form as: Phytomedicine. 2009 Mar 19;16(5):391–400. doi: 10.1016/j.phymed.2009.02.002

Table 3.

The side-effect rate ratios (silymarin compared to placebo) with 95% confidence intervals.

	Rate Ratio	(95% CI)	Silymarin Complaints/person-visits	Placebo Complaints/person-visits	P-value
Abdominal Pain	1.01	(0.50, 2.05)	17/261	15/232	0.99
Diarrhea	1.48	(0.66, 3.57)	15/263	9/236	0.35
Nausea	0.89	(0.27, 2.91)	6/260	6/231	0.84
Vomiting	0.55	(0.10, 2.32)	3/260	5/232	0.41
Constipation	0.37	(0.05, 1.8)	2/260	5/231	0.23
Increased fatigue	0.39	(0.08, 1.45)	3/260	7/231	0.16
Insomnia	1.30	(0.20, 11.2)	3/260	2/231	0.78
Skin Rash	NA^*	--	0/260	0/231	NA^*

No participants reported skin rash during follow-up

Methods: rate ratios calculated by median-unbiased estimation and confidence intervals calculated using exact methods.

CI, confidence interval; NA, not applicable