Table 1.

Neural activations during social exclusion vs. inclusion that correlated positively with increases in IL-6 levels from baseline to two hours post-injection for all participants in the endotoxin group, (p < .001, 10-voxel extent threshold). There were no regions that correlated negatively with IL-6 increases. R(ΔDep) refers to the correlation between the parameter estimates from the listed neural activations and self-reported increases in depressed mood. * p< .05; ^S p < .10

Region	BA	MNI Coordinate	T	k	R (ΔDep)
Paralimbic
Left Anterior Insula		-20 28 -4	7.83	158	.09
Right Anterior Insula		48 20 -8	7.69	306	.40^A
Left Posterior Insula		-46 -18 12	4.55	81	.51*
Right Posterior Insula		46 -14 12	4.36	31	.26
Perigenual Anterior Cingulate	32	-8 40 8	4.41	21	.33
Posterior Cingulate Cortex	31	-16 -22 36	4.89	14	.20
Posterior Cingulate Cortex	31	14 -40 14	4.14	12	.08
Caudate		12 16 2	4.77	58	.41^A
Frontal Lobe
Dorsomedial Prefrontal Cortex (PFC)	9	-8 60 40	6.00	52	.10
Dorsomedial PFC	9	-10 46 54	5.42	23	.36
Dorsomedial PFC	9	18 56 42	5.33	33	.09
Dorsomedial PFC	8	18 24 62	5.22	23	.07
Dorsomedial PFC	8	-2 28 54	4.11	17	.41^A
Left Dorsolateral PFC	9	-34 46 38	5.01	16	.17
Right Rostrolateral PFC	10	30 68 12	4.15	24	.43^A
Medial PFC	10	-6 62 4	4.02	18	.42^A
Right Dorsal Premotor Cortex	6	60 6 40	5.08	30	.25
Supplementary Motor Area	4/6	0 -26 68	5.58	73	.07
Supplementary Motor Area	6	-6 8 74	4.62	12	.49*
Supplementary Motor Area	6	12 -20 72	4.39	31	.20
Left Premotor Cortex	4	-20 -22 54	4.29	13	.10
Parietal Lobe
Left Somatosensory Cortex	1/2/3	-24 -28 64	4.32	17	.26
Precuneus	7	16 -42 66	4.55	50	.14
Temporal Lobe
Right Inferior Temporal Gyrus	20	46 -12 -30	4.95	47	.51*
Temporal Pole	38	-46 10 -40	4.65	22	.41^A
Left Middle Temporal Gyrus	21	-54 -8 -12	4.40	58	.49*
Right Middle Temporal Gyrus	21	62 -10 -12	4.19	15	.34
Right Middle Temporal Gyrus	21	58 -2 -16	4.06	20	.53*
Posterior Superior Temporal Sulcus	22	62 -26 0	4.58	72	.18
Posterior Superior Temporal Sulcus	22	-58 -32 4	4.48	21	.17
Posterior Superior Temporal Sulcus	22	-52 -38 10	4.16	13	.57*
Right Fusiform Gyrus	37	46 -42 -12	4.34	19	.35
Occipital Lobe
Occipital Cortex	18	0 -74 14	4.95	48	.39^A
Occipital Cortex	17	-10 -66 14	4.80	18	.38
Occipital Cortex	19	28 -54 2	3.88	15	.40^A
Cerebellum
Cerebellum		20 -60 -38	6.03	69	.23
Cerebellum		-40 -68 -34	5.22	35	.15
Cerebellum		-18 -46 -12	5.10	57	.42^A
Cerebellum		-24 -56 -42	4.88	17	.35
Cerebellum		-10 -60 -12	4.71	19	.48*
Cerebellum		8 -40 -30	4.67	42	.32
Cerebellum		-4 -84 -38	3.91	10	.16