Table 3.

Genes Changed by Nano-Onion and Nanotube but Fall in the Category of “Transport” (Golgi Vesicle Transport, Membrane Fusion, Secretory Pathway, Intracellular Transport)^a

gene category	gene symbol	gene name	fold change of gene expression
Fold Change of Gene Expression for Onion, 0.6 μg/mL
Golgi vesicle transport	COPA	coatomer protein complex, subunit alpha	0.57
	SNAP23	synaptosomal-associated protein	0.30
	GBF1	golgi-specific brefeldin A resistance factor 1	2.45
	NAPG	N-ethylmaleimide-sensitive factor attachment protein, gamma	0.48
	NAPA	N-ethylmaleimide sensitive fusion protein attachment protein alpha	0.60
membrane fusion	NAPA	N-ethylmaleimide sensitive fusion protein attachment protein alpha	0.60
	NAPG	N-ethylmaleimide-sensitive factor attachment protein, gamma	0.48
	SNAP23	synaptosomal-associated protein	0.30
secretory pathway	NAPA	N-ethylmaleimide sensitive fusion protein attachment protein alpha	0.60
	COPA	coatomer protein complex, subunit alpha	0.57
	GBF1	golgi-specific brefeldin A resistance factor 1	2.45
	NAPG	N-ethylmaleimide-sensitive factor attachment protein, gamma	0.48
	SCD	stearoyl-CoA desaturase	0.19
	SNAP23	synaptosomal-associated protein	0.30
intracellular transport	GBF1	golgi-specific brefeldin A resistance factor 1	2.45
	DST	dystonin	0.40
	NAB2	NGFI-A binding protein 2	0.43
	SNAP23	synaptosomal-associated protein	0.30
	KDELR3	KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3	0.76
	NAPG	N-ethylmaleimide-sensitive factor attachment protein, gamma	0.48
	COPA	coatomer protein complex, subunit alpha	0.57
	HNRPA1	heterogeneous nuclear ribonucleoprotein A 1	2.49
	NAPA	N-ethylmaleimide sensitive fusion protein attachment protein alpha	0.60
nucleocytoplasmic transport	NAB2	NGFI-A binding protein 2	0.43
	HNRPA1	heterogeneous nuclear ribonucleoprotein A 1	2.49
Fold Change of Gene Expression for Tube, 0.06 μg/mL
Golgi vesicle transport	COPA	coatomer protein complex, subunit alpha	0.57
	NAPA	N-ethylmaleimide sensitive fusion protein attachment protein alpha	0.60
	GBF1	Golgi-specific brefeldin A resistance factor 1	2.45
membrane fusion	NAPA	N-ethylmaleimide sensitive fusion protein attachment protein alpha	0.60
secretory pathway	COPA	coatomer protein complex, subunit alpha	0.57
	NAPA	N-ethylmaleimide sensitive fusion protein attachment protein alpha	0.60
	SCD	stearoyl-CoA desaturase	0.19
	GBF1	Golgi-specific brefeldin A resistance factor 1	2.45
intracellular transport	GBF1	Golgi-specific brefeldin A resistance factor 1	2.45
	NAPA	N-ethylmaleimide sensitive fusion protein attachment protein alpha	0.60
	COPA	coatomer protein complex, subunit alpha	0.57

^aFold change of gene expression is given for the low dose (0.6 μg/mL for MWCNO and 0.06 μg/mL for MWCNT). Fold changes represent the ratio of MRNA amount of treated samples divided by those of control samples.