Figure 6.

These are the P‐maps for clinical covariates broken down by diagnosis, where blue implies P‐values of 0.1 or greater. They show where a correlation between radial atrophy and clinical score can be detected within each of the three diagnostic groups. The significance of each of these maps, assessed by permutation, is shown in Table V. Associations with sum‐of‐boxes CDR (left panels) are very strong for both left and right hippocampi in AD and MCI, but not in controls. The global CDR scores (middle panels) associate with atrophy only in AD, but not in MCI or controls, as all MCI patients have a global CDR value of 0.5 and all controls have a global CDR of 0. Associations with MMSE are weaker than expected (only significant in MCI on the right), perhaps because MMSE was used to help define diagnosis, leading to a very restricted range of MMSE scores in each map. [Color figure can be viewed in the online issue, which is available at www.interscience.wiley.com.]