Table VI.

Permutation testing for the p‐maps of Figure 7, where those in italics are deemed significant

	Left	Right
Normal vs. MCI	0.149	0.171
Normal vs. AD	0.00282	0.00669
MCI vs. AD	0.0309	0.0607
MMSE	0.0483	0.0395
Global CDR	0.258	0.247
Sum of boxes CDR	0.00908	0.00148

These show the significance of factors hypothesized to be associated with regional hippocampal atrophy. Most of these tests show significant effects and are controlled for the effects of age, sex, ApoE status and (in the case of the last three) for diagnosis. Only the least discriminative test (global CDR has only 5 possible scores), and the most subtle diagnostic comparison (MCI v. normal), were not significant. This may be because of the anatomically restricted area, in the hippocampal head, where atrophy is greater in MCI than in controls at the voxel level.