Table 2.

STAT1-regulated genes with increased expression in blood from patients with sarcoidosis.

Gene. Symbol	Gene Title	Mean FC*	q-value**	Representative functions
MHC2TA	Major histocompatibility complex, class II, transactivator	1.23	0.029	Master of regulator of MHC class II genes [51]
IRF1	Interferon regulatory factor 1	1.45	0.002	Nuclear factor and a transcriptional factor for type I IFN [52], can induce CDKN1A activity
WARS	Tryptophanyl-tRNA synthetase	1.72	0.001	Antagonist of VEGF [53]
PSMB9	Proteasome subunit, beta-type, 9	1.42	0.002	Transport protein into the endoplasmic reticulum, important in MHC class I regulation [54]
CD64	Fc fragment of IgG, high affinity	3.14	0.029	Fc fragment of IgG receptor, expressed on human monocytes and macrophages [55]
CXCL9	Chemokine CXC motif, ligand 9	1.16	0.029	T-cell chemoattractant
PIM1	Oncogene PIM1	1.39	0.009	Protooncogene in prostate cancer and hematopoietic malignancies [56]
CCND1	Cyclin D1	1.16	0.029	Function as an oncogene, related to lymphoma, leukemia [57], parathyroid tumor [58], and colorectal cancer [59]
CDKN1A	Cyclin-dependent kinase inhibitor 1A	1.36	0.029	Inhibitor of protein kinase, CDK1
A2M	Alpha-2-macroglobulin	1.15	0.029	Major plasma proteinase inhibitor
OPRM-1	Opioid receptor, mu-1	1.15	0.029	Pain-related gene
MT1E	Metallothionein 1E	1.31	0.012	Heavy metal-binding protein, Zn and Cu homeostasis
TRH	Thyrotropin-releasing hormone deficiency	1.14	0.029	Major hypothalamic mediator of thyroid stimulating hormone release

^*Fold change,

^**the maximum q-value in case of multiple probe sets