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Reelin-induced phosphorylation of n-cofilin involves ApoER2 and VLDLR. In cortical lysates prepared from E18 wild-type mice and treated with recombinant Reelin the protein levels of phosphorylated cofilin (p-cofilin) are much higher when compared to those from ApoER2-/- mice. Levels of p-cofilin were only slightly reduced in VLDLR-/- tissue. Actin was used as a loading control.
