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. Author manuscript; available in PMC: 2010 Jan 1.
Published in final edited form as: Annu Rev Biochem. 2009;78:363–397. doi: 10.1146/annurev.biochem.78.082307.091526

Figure 4.

Figure 4

Deubiquitination of histones H2A and H2B regulate chromatin structure and activity. Panel A details the dynamic ubiquitination/deubiquitination of H2B in yeast. These DUBs are localized to sites of action by interaction with other chromatin bound proteins that act as scaffolds and activate the DUB activity. Panel B shows the ubiquitination/deubiquitination of H2A in higher eukaryotes. A putative binding partner for UBP16 with a role in chromatin condensation is shown with question marks.