Figure 5. Requirement for recipient B cells for CD8 T cell tolerance induction.
(A) B cell-deficient μMT and WT B6 mice received T cell-depleted B10.A BMT after 3 Gy TBI/anti-CD154. The incidence of WBC granulocyte chimerism is shown at indicated times. One of two similar experiments is shown (7-8 animals/group/experiment). (B) WBC granulocyte and CD4 chimerism (±SEM) for groups in A. (C) Mice treated as in panel A also received depleting anti-CD8 mAb. Incidence of granulocyte chimerism is shown at indicated times. One of two similar experiments is shown (7-8 animals/group/experiment). (D) WBC granulocyte and CD4 chimerism levels (±SEM) for groups in C.