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. 2009 Jun 1;26(9):2031–2040. doi: 10.1093/molbev/msp109

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© The Author 2009. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org

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FIG. 2.— — Expected distributions under neutrality of the test statistic D. The observed D statistic in vertebrates, indicated as D_Obs, has the same value in the neutrality and exchangeability tests (no changes other than between Sec and Cys were found). The distributions used in each test are depicted together in each panel. (A) Neutral distribution of the proportion of divergent Sec sites (D_Sec→aa), in blue, and neutral distribution of the proportion of divergent Sec sites (D_Sec→Cys) in the Sec/Cys exchangeability test, in red; (B) Neutral distribution of the proportion of divergent Cys sites (D_Cys→aa), in blue, and neutral distribution of the proportion of divergent Cys sites (D_Cys→Sec) in the Sec/Cys exchangeability test, in green. Due to the small number of simulated Cys sites (n = 10), the discrete D_Cys→Sec distribution does not contain values in all bins.