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. Author manuscript; available in PMC: 2010 Jan 20.
Published in final edited form as: Circulation. 2008 Dec 31;119(2):269–280. doi: 10.1161/CIRCULATIONAHA.108.773424

Figure 5.

Figure 5

Effects of the absence of SPARC (Secreted Protein Acidic and Rich in Cysteine) and the imposition of TAC (transverse aortic constriction) on myocardial diastolic stiffness. WT = wild-type littermate mice C57Bl6/SV129, SPARC Null = mouse created using targeted gene deletion to prevent expression of SPARC. * = p < 0.05 vs. WT, # = p < 0.05 vs. SPARC Null, & = p < 0.05 vs. WT TAC.

Panel A: Examples of the passive diastolic myocardial stress vs. strain curves for the four groups of animals studied: WT control, WT TAC, SPARC Null control, SPARC Null TAC.

Panel B: Mean ± SEM values of the passive stiffness constant, β, for the four groups of animals studied.