Table 1.

Levels of total NNN, total NNAL, and total NNN as a percent of total NNAL in the urine of 20 subjects who stopped smoking and used the nicotine patch

	Total NNN, pmol/ml urine						Total NNAL, pmol/ml urine						Total NNN as % of total NNAL
		weeks on patch						weeks on patch						weeks on patch
Subject	BL	4	8	16	24	28	BL	4	8	16	24	28	BL	4	8	16	24	28
1	0.146	0.010	0.002	0.005	0.004	0.008	1.06	0.40	0.06	0.03	0.03	0.04	14	3	3	17	12	23
2	0.072	0.007	0.006	0.014	0.010	NA	0.92	0.06	0.05	0.02	0.01	LOQ	8	12	12	58	170	NA
3	0.227	0.016	0.021	0.017	0.004	S	0.93	0.17	0.06	0.05	0.03	S	25	9	34	32	12	NA
4	0.068	0.009	0.006	0.005	NA	0.003	0.42	0.08	0.05	0.01	LOQ	0.01	16	11	13	56	NA	60
5	0.236	0.022	0.016	0.006	0.005	0.006	1.28	0.13	0.05	0.01	0.02	0.01	19	17	30	43	29	100
6	0.059	0.061	0.062	0.020	0.009	0.061	0.17	0.10	0.02	0.01	0.01	0.03	35	62	410	330	110	230
7	0.064	0.017	NA	0.024	0.013	0.003	0.24	LOQ	0.04	0.02	0.03	LOQ	27	NA	NA	160	42	NA
8	0.163	0.033	0.012	0.007	0.002	0.003	0.75	0.05	0.05	0.03	0.05	0.03	21	65	26	27	4	11
9	0.154	0.015	0.017	0.016	LOQ	0.009	2.38	0.12	0.08	0.04	0.23	NA	6	13	22	46	NA	NA
10	0.015	0.002	0.001	0.005	0.002	LOQ	0.45	0.27	0.16	0.16	0.05	0.07	3	1	1	3	4	0
11	0.049	0.003	LOQ	0.016	NA	0.009	1.70	NA	0.07	0.05	NA	NA	3	NA	NA	33	NA	NA
12	0.347	0.073	0.419	0.034	NA	NA	1.69	NA	LOQ	0.01	NA	NA	21	NA	NA	310	NA	NA
13	0.030	LOQ	0.029	0.007	0.016	NA	0.53	0.07	0.03	LOQ	0.08	NA	6	NA	85	NA	19	NA
14	0.084	LOQ	0.023	LOQ	0.021	NA	2.30	0.16	0.05	0.09	0.06	NA	4	NA	49	NA	34	NA
15	0.188	0.046	NA	S	0.015	NA	2.95	0.35	0.13	S	0.17	NA	7	13	NA	NA	9	NA
16	0.007	0.006	0.012	LOQ	0.007	NA	0.10	0.13	0.03	LOQ	LOQ	NA	7	5	48	NA	NA	NA
17	0.067	0.013	0.010	LOQ	0.004	NA	1.37	0.22	LOQ	0.07	0.09	NA	5	6	NA	NA	5	NA
18	0.299	0.157	0.050	0.022	0.012	NA	0.99	0.11	0.04	0.02	0.02	NA	30	150	130	110	71	NA
19	0.039	0.005	0.020	0.001	0.007	NA	0.85	0.11	LOQ	LOQ	0.04	NA	5	5	NA	NA	16	NA
20	0.024	0.002	0.003	0.002	0.016	NA	0.18	0.08	0.03	0.03	0.05	NA	13	2	10	8	36	NA
Mean	0.117	0.028	0.042	0.013	0.009	0.013	1.07	0.15	0.06	0.04	0.06	0.03	14	25	63	88	38	70
SD	0.099	0.039	0.099	0.009	0.006	0.020	0.80	0.10	0.04	0.04	0.06	0.02	10	39	110	110	46	85
Median	0.070	0.014	0.016	0.011	0.008	0.007	0.93	0.12	0.05	0.03	0.05	0.03	10	11	28	45	19	42

Note. BL, baseline (before cessation of smoking); NA, not analyzed; LOQ, below the limit of quantitation (∼0.001 pmol/ml urine for NNN and ∼0.03 pmol/ml urine for NNAL); S, smoking at this time point according to anatabine analysis.