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PKR inhibitor blocks SG-induced proapoptotic genes in undifferentiated and NGF-differentiated PC-12 cells. (A) Undifferentiated and (B) NGF-differentiated PC-12 cells (5 × 105/ml) were treated with or without PKR inhibitor (PKRI) C16 at 2.5μM for 30 min prior to addition of SG (10 ng/ml) or its vehicle (VH). Relative mRNA expression of proapoptotic genes was measured 18 h later. Data are mean ± SEM (n = 3). Bars without the same letter differ (p < 0.05).
