FIG. 4.

Induction of 28S rRNA cleavage in RAW 264.7 cells by DON, T-2 and ricin. Cells were treated with DON (A), T-2 (C), or ricin (E) at indicated concentrations for 6 h or with DON (2 μg/ml) (B), T-2 (80 ng/ml) (D), or ricin (160 ng/ml) (F) for indicated time intervals and analyzed as described in Figure 3 legend. Arrows indicate 28S rRNA cleavage products. Results are representative of four separate experiments.