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DON, T-2, and ricin induce RNase activity in RAW 264.7 cells. Cells were treated with DON (A), T-2 (C), or ricin (E) at indicated concentrations for 1 h or with DON (1000 ng/ml) (B), T-2 (160 ng/ml) (D), or ricin (320 ng/ml) (F) for indicated time intervals Total cellular proteins were extracted and RNase activity determined. Data are means ± SEM (n = 6) pooled from three separate experiments. Bars without same letter differ (p < 0.05).
