TABLE 1.

Hepatotoxicity of Inorganic Arsenic in Humans

Major lesions	Arsenic exposure source	Location	Results	Reference
Abnormal liver function	Drinking water	India	Elevated ALT, AST, ALP	Mazumder, 2005
	Burning arsenic coal	China	Elevated ALT, AST	Liu et al., 1992
Hepatomegaly	Drinking water	India	77% of hospitalized arsenicosis patients	Santra et al., 1999
Drinking water	India		10% of arsenic exposed population	Mazumder, 2005
	Burning arsenic coal	China	37% of hospitalized arsenicosis patients	Liu et al., 1992
Burning arsenic coal	China		21% of arsenic exposed population	Zhang et al., 2000
Hepatoportal sclerosis	Fowler's solution	Worldwide	Case reports from medicinal use of arsenic	Nevens et al., 1990
	Drinking water	India	Case reports, correlation with liver arsenic	Santra et al., 1999
Liver fibrosis and cirrhosis	Fowler's solution	Worldwide	Case reports with liver arsenic	Dhawan et al., 1983
	Drinking water	India	Liver fibrosis	Mazumder, 2005
	Burning arsenic coal	China	Liver fibrosis	Lu et al., 2001

Note. ALT, alanine aminotransfease; AST, aspartate aminotransferase; ALP, alkaline phosphatase.