Table 4.

Genes downregulated (≥1.5 fold) in lupus patients homozygous for the lupus-associated MECP2 risk haplotype as compared to lupus patients homozygous for the MECP2 protective haplotype

Gene	Definition/Description	Ratio Risk/Protective	Associative P value
AP3M2	Adaptor-related protein complex 3, mu 2 subunit	0.64	2.81×10−06
CD80	CD80 antigen (CD28 antigen ligand 1, B7-1 antigen)	0.62	3.12×10−08
CLIC2	Chloride intracellular channel 2	0.53	1.96×10−09
CRY1	Cryptochrome 1 (photolyase-like)	0.53	3.97×10−51
FUCA1	Fucosidase, alpha-L- 1, tissue	0.63	1.77×10−04
GCET2	Germinal center expressed transcript 2, transcript variant 2	0.57	1.86×10−05
HDGFRP3	Hepatoma-derived growth factor, related protein 3	0.58	3.68×10−27
HRASLS3	HRAS-like suppressor 3	0.61	5.99×10−08
HSPA4L	Heat shock 70kDa protein 4-like	0.65	1.34×10−10
KDELC2	KDEL (Lys-Asp-Glu-Leu) containing 2	0.63	7.11×10−34
LOC134147	Similar to mouse 2310016A09Rik gene	0.52	1.29×10−07
LRPPRC	Leucine-rich PPR-motif containing	0.66	3.97×10−25
MYC	V-myc myelocytomatosis viral oncogene homolog (avian)	0.63	1.87×10−07
PEG10	Paternally expressed 10, transcript variant 1	0.66	1.95×10−10
PRRT3	Proline-rich transmembrane protein 3	0.64	1.17×10−05
RASGRP1	RAS guanyl releasing protein 1 (calcium and DAG-regulated)	0.58	6.84×10−11
RPS7	Ribosomal protein S7	0.66	7.04×10−04
SACS	Spastic ataxia of Charlevoix-Saguenay (sacsin)	0.64	7.06×10−42
SMARCA2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2, transcript variant 2	0.59	4.75×10−07
SORD	PREDICTED: Sorbitol dehydrogenase	0.64	2.77×10−05
STEAP3	STEAP family member 3, transcript variant 2	0.64	1.25×10−06
TEX15	Testis expressed sequence 15	0.50	5.83×10−62
TGFBR3	Transforming growth factor, beta receptor III	0.48	7.92×10−13
TMOD1	Tropomodulin 1	0.50	6.25×10−06