Table 5.
IRIDESCENT algorithm analysis showing shared relationships identified in MEDLINE with genes that are differentially expressed as a result of the MECP2 haplotype present. The ratio of observed to expected relationships (Obs/Exp) is given below, which reflects a statistical enrichment score for the association. The empirically determined average Obs/Exp ratio for a list of 128 genes is 1.42 ± 0.07. Only associations greater than 3 standard deviations were reported.
| Shared relationship | Genes shared | Obs/Exp |
|---|---|---|
| Histone deacetylase | 14 | 2.48 |
| BDNF | 13 | 2.12 |
| Interferon-inducible | 13 | 4.53 |
| Chromatin structure | 12 | 2.15 |
| CREB1 | 12 | 2.03 |
| Hypermethylation | 11 | 2.36 |
| Trichostatin A | 11 | 2.83 |
| CpG methylation | 9 | 3.61 |
| Promoter methylation | 8 | 2.69 |
| Aberrant methylation | 7 | 3.61 |