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. Author manuscript; available in PMC: 2009 Aug 28.
Published in final edited form as: Nanomedicine (Lond). 2008 Apr;3(2):247–265. doi: 10.2217/17435889.3.2.247

Figure 7. Schematic illustrating Polycefin reaction with different cells in a human U87MG brain tumor xenograft model in mice.

Figure 7

Polycefin contains mAbs to mouse TfR and tumor cell surface antigen. Binding of antimouse TfR to mouse endothelium causes drug internalization and transcytosis, whereby it becomes available to glioma cells that bind Polycefin through the attached 2C5 antibody. mAb: Monoclonal antibody; TfR: Transferrin receptor.