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. Author manuscript; available in PMC: 2010 Jul 1.
Published in final edited form as: Curr Opin Clin Nutr Metab Care. 2009 Jul;12(4):350–356. doi: 10.1097/MCO.0b013e32832c932d

Figure 1.

Figure 1

Genetic linkage between caloric restriction (CR) and SIRT1. CR enhances mitochondrial biogenesis by up-regulating the expression of the endothelial nitric oxide synthase (eNOS), promoting the production of NO, and increasing SIRT1 expression (left). The activation of PGC-1α by SIRT1 likely mediates the effect of CR on mitochondria. CR also enhances physical activity likely by increasing NAD content (right) and up-regulating SIRT1 protein levels (middle) in the brain. SIRT1 is also required for the metabolic adaptation to CR, although the underlying mechanism is unknown.