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. Author manuscript; available in PMC: 2010 Jul 1.
Published in final edited form as: Curr Opin Clin Nutr Metab Care. 2009 Jul;12(4):350–356. doi: 10.1097/MCO.0b013e32832c932d

Figure 3.

Figure 3

Possible trade-offs between robustness in metabolism and frailty in infection in CR. Trade-offs between robustness and frailty are an inherent, unavoidable feature of complex systems, such as biological systems. Whereas CR promotes metabolic robustness, it appears to increase frailty to infections pathogens. Given that sirtuin (SIRT1 in particular) activating compounds (STACs) function as a potential CR mimetics, STACs might also convey similar trade-offs. Therefore, it will be critical to seek an optimal balance between robustness in metabolism and frailty in infection in our complex physiological system.