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. Author manuscript; available in PMC: 2009 Aug 28.
Published in final edited form as: Eur J Immunol. 2008 Dec;38(12):3411–3425. doi: 10.1002/eji.200838432

Figure 2. RF mice exhibit defective B lineage dependent immune responses.

Figure 2

Proliferation of CD43-depleted splenic B cells in response to (A) anti-CD40 Abs, and (B) LPS. (C) IL-10 production of splenic B cells in response to LPS. (D) Anti-TNP IgM and (E) anti-TNP IgG3 production in serum of mice challenged with the T-independent antigen, TNP-Ficoll. (F) Anti-TNP IgG1 production upon challenge with the T-dependent antigen, TNP-KLH. All the serum samples were diluted at 1:10 and then applied to ELISA assay for detection of antibody responses. The results are representative data from three similar experiments.