CUS increases certain depression-like behaviors in females. (A–B) Females, but not males, show a poorer fur state after CUS and there is an additional effect of genotype. (C–D) CUS results in significant alterations in sucrose consumption in female and male mice. Female stressed KOs consumed significantly less sucrose than both nonstressed KOs and stressed CTLs (* p<0.05). (E–F) In the novelty suppressed feeding task, stress significantly increased latency to feed in female mice (F1,43 =8.79, p<0.005) but no effect in male behavior, and both stressed CTL and KO females took significantly longer to feed than their unstressed cohorts (p<0.05). However, there was a significant difference in male feeding behavior after stress in CTL mice compared to both nonstressed CTLs and stressed KOs(p<0.05).