Table 1.
Intestinal proCCK and its products in PC knockout mice and corresponding wild-type controls [picomoles per gram tissue (mean ± sem)]a
| Knockout | Wild type | P value | |
|---|---|---|---|
| PC1/3 (n = 4) | |||
| ProCCK | 187.3 ± 40.3 | 4.8 ± 1.5 | <0.001 |
| CCK-Gly-Arg | 5.6 ± 1.4 | <0.1 | <0.001 |
| CCK-Gly | 16.5 ± 6.0 | 7.0 ± 1.6 | <0.02 |
| CCK-amide | 6.3 ± 0.6 | 75.3 ± 6.3 | <0.001 |
| PC 2 (n = 8) | |||
| ProCCK | 7.4 ± 1.2 | 7.3 ± 1.1 | >0.05 |
| CCK-Gly-Arg | 4.0 ± 0.8 | 5.6 ± 0.8 | >0.05 |
| CCK-Gly | 4.0 ± 0.5 | 3.1 ± 0.4 | >0.05 |
| CCK-amide | 64.3 ± 9.5 | 57.3 ± 9.8 | >0.05 |
a
The PC 2 knockout results shown for comparison are published elsewhere (20).