Table 2.

Fractional AUC of proCCK and its products calculated from chromatographic curves of tissue extracts from PC1/3 knockout mice and corresponding wild-type controls [AUC (percentage of individual chromatographic curve (mean ± sem; n = 4])]

	PC1/3 knockout	Wild type	P value
Intestinal proCCK and its products (see Fig. 2)
ProCCK	14 ± 6	<5	<0.001
CCK-Gly-(Arg)	83 ± 27	100	>0.05
CCK-83a	<5	8 ± 3	<0.02
CCK-22a	100	57 ± 21	<0.05
CCK-8a	<5	32 ± 10	<0.001
Cerebral proCCK and its products (see Fig. 3)
ProCCK	<5	<5	>0.05
CCK-Gly-(Arg) I	42 ± 19	10 ± 4	<0.001
CCK-Gly-(Arg) II	16 ± 5	55 ± 19	<0.001
CCK-Gly-(Arg) III	35 ± 14	<5	<0.001
CCK-Gly-(Arg) IV	<5	34 ± 13	<0.001
CCK-83a	12 ± 5	<5	<0.01
CCK-8a	86 ± 14	100	>0.05

^aCarboxyamidated CCK.