Table 3.
Cerebral proCCK and its products in PC knockout mice and corresponding wild-type controls [picomoles per gram tissue (mean ± sem)]a
| Knockout | Wild type | P value | |
|---|---|---|---|
| PC1/3 (n = 4) | |||
| ProCCK | 16.8 ± 4.6 | 10.5 ± 2.2 | >0.05 |
| CCK-Gly-Arg | <0.1 | <0.1 | >0.05 |
| CCK-Gly | 26.2 ± 3.6 | 24.0 ± 3.0 | >0.05 |
| CCK-amide | 98.5 ± 4.6 | 97.1 ± 9.0 | >0.05 |
| PC 2 (n = 8) | |||
| ProCCK | 97.1 ± 16.5 | 11.3 ± 1.5 | <0.001 |
| CCK-Gly-Arg | 1.5 ± 0.4 | 3.0 ± 0.5 | >0.05 |
| CCK-Gly | 48.8 ± 6.3 | 28.4 ± 1.7 | <0.001 |
| CCK-amide | 88.0 ± 5.5 | 118.2 ± 8.1 | <0.01 |
a
The PC 2 knockout results shown for comparison are published elsewhere (20).