Table 1. Characteristics of Seronegative Control and Human Immunodeficiency Virus–Positive Patients at Baseline and at 1 Year (Mean ± Standard Error).
| Characteristics | SN Control Subjects (n = 32) |
HIV Patients (n = 31) |
pa | |||||
|---|---|---|---|---|---|---|---|---|
| Baseline | 1 Year | Baseline | 1 Year | SN Controls (baseline vs 1 year) |
HIV Patients (baseline vs 1 year) |
Control vs HIV Patients at Baseline | Control vs HIV Patients at 1 Year | |
| Age, yr | 46.9 ± 2.3 | 48.0 ± 2.3 | 49.6 ± 1.5 | 50.6 ± 1.5 | — | — | 0.44 | 0.44 |
|
| ||||||||
| Education, yr | 15.5 ± 0.4 | 15.5 ± 0.4 | 15.5 ± 0.4 | 15.7 ± 0.4 | — | — | 0.94 | 0.73 |
|
| ||||||||
| Nadir CD4, number/mm3 | — | — | 152 ± 24 | 142 ± 25 | — | 0.14 | — | — |
|
| ||||||||
| CD4, number/mm3 | — | — | 415 ± 40.4 | 454 ± 42 | — | 0.06 | — | — |
|
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| Log viral load, copies/ml | — | — | 2.24 ± 0.20 | 2.08 ± 0.16 | — | 0.24 | — | — |
|
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| HIV Dementia Scale (0-16) | — | — | 14.6 ± 0.3 | 14.9 ± 0.3 | — | 0.41 | — | — |
|
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| Clinical Dementia Rating (0-3) | — | — | 0.27 ± 0.06 | 0.27 ± 0.06 | — | 1.0 | — | — |
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| Karnofsky score (0-100) | — | — | 93.5 ± 1.4 | 91.6 ± 1.5 | — | 0.11 | — | — |
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| ||||||||
| CES-D | 6.0 ± 1.1 | 6.6 ± 1.0 | 9.0 ± 1.7 | 9.6 ± 1.2 | 0.56 | 0.78 | 0.14 | 0.07 |
|
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| Estimated verbal IQb | 114.0 ± 1.4 | — | 111.4 ± 1.3 | — | — | — | 0.17 | — |
a
p values are from post hoc analyses between any two groups as indicated.
b
Estimated premorbid verbal intelligence quotient [IQ] is derived from the National Adult Reading Test. SN = seronegative; HIV = human immunodeficiency virus; CES-D = Center for Epidemiological Studies Depression Scale.