Figure 2.

Sensitivity of native P2X2/3 receptor activity to PIP₃ depletion in DRG neurons. A) Sample traces demonstrating the effects of 35 μM (middle) and 100 nM wortmannin incubation (2 h) (right) on P2X2/3 response to 10 μM α,β-meATP in DRG (control on left). B) Pooled data of P2X2/3 responses to 10 μM α,β-meATP under control condition, after 2 h incubation with 35 μM or 100 nM wortmannin (N = 5–6). (**, P < 0.01)