Table 1.

List of genes used in this analysis.

Name	Protein name	Protein class	Main function
COL1A1	Type I collagen alpha 1 chain	Structural component	Cartilage and connective tissue collagen
COL1A2	Type I collagen alpha 2 chain	Structural component	Cartilage and connective tissue collagen
MMP1	Matrix metalloprotease 1 (interstitial collagenase)	Protease	Cleavage of collagen I, II, and III
MMP3	Matrix metalloprotease 3 (stromelysin 1)	Protease	ECM component degradation
MMP9	Matrix metalloprotease 9 (gelatinase B)	Protease	Cleavage of collagen IV and V
MMP13	Matrix metalloprotease 13 (collagenase 3)	Protease	Cleavage of collagen I and III
TIMP1	Tissue inhibitor of metalloprotease 1 (collagenase inhibitor)	Protease inhibitor	Inhibits matrix metalloproteases, and others
ETS1	v-ets erythroblastosis virus E26 oncogene homolog 1	Transcription factor	Erythroblast and fibroblast transformation
FOS	v-fos FBJ murine osteosarcoma viral oncogene homolog	Component of AP-1	Regulator of proliferation, differentiation, and transformation
JUN	v-jun avian sarcoma virus 17 oncogene homolog	Component of AP-1	Regulator of proliferation, differentiation, and transformation
JUNB	jun B proto-oncogene	Component of AP-1	Regulator of proliferation, differentiation, and transformation
JUND	jun D proto-oncogene	Component of AP-1	Regulator of proliferation, differentiation, and transformation
NKFB1	Subunit 1 of nuclear factor kappa-B	Component of NF-κB	Involved in many biological processes
SMAD3	SMA- and MAD-related protein 3	Transcriptional modulator	Mediator of signal transduction by TGFβ1 (RSMAD)
SMAD4	SMA- and MAD-related protein 4	Transcriptional modulator	Mediator of signal transduction by TGFβ1 (CoSMAD)
SMAD7	SMA- and MAD-related protein 7	Transcriptional modulator	Antagonist of signalling by TGFβ1 (ISMAD)
TNF	Tumour necrosis factor alpha	Cytokine	Proinflammatory role
TGFB1	Transforming growth factor beta 1	Growth factor	Involved in proliferation and differentiation